Polymorphisms in the human tropoelastin gene modify in vitro self-assembly and mechanical properties of elastin-like polypeptides.
Elastin is a major structural component of elastic fibres that provide properties of stretch and recoil to tissues such as arteries, lung and skin.Remarkably, after initial deposition of elastin there is normally no subsequent turnover of this protein over the course of a lifetime.Consequently, elastic fibres must be extremely durable, able to with